In 2025, the Democratic Republic of the Congo documented 26,064,143 malaria infections, with 29,938 fatalities. The Ituri province launched a large-scale treatment initiative, targeting regions with high malaria prevalence. The campaign aims to reduce malaria cases and improve early detection. The DRC remains among the countries with the highest malaria burden globally, contributing to 11.7% of all malaria deaths in Africa. The R21 vaccine was introduced in 2024 to further enhance malaria prevention efforts, with the initial phase targeting children in Kongo Central.